Application Using Threads (ApplicationUsingThreads): The driver coordinates concurrent database operations (operations from different threads) by acquiring locks. Although locking prevents errors in the driver, it also decreases performance. If your application does not make ODBC calls from different threads, the driver has no reason to coordinate operations. In this case, the ApplicationUsingThreads attribute should be disabled (set to 0).
Failover Mode (FailoverMode): Although high availability that replays queries after a failure provides increased levels of protection, it can adversely affect performance because of increased overhead.